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    When no review was identified, we either cited all relevant individual studies, or if too numerous, a representative sample of the literature.Some items had little or no identified empirical evidence (eg, title) but their inclusion in the checklist is supported by a strong pragmatic or ethical rationale.High quality protocols facilitate proper conduct, reporting, and external review of clinical trials.However, the completeness of trial protocols is often inadequate.We strongly recommend that this explanatory paper be used in conjunction with the SPIRIT Statement. The SPIRIT 2013 Explanation and Elaboration paper, together with the Statement, should help with the drafting of trial protocols.

    For each checklist item we also strived to provide references to empirical data supporting its relevance, which we identified through a systematic review conducted to inform the content of the SPIRIT checklist.To help improve the content and quality of protocols, an international group of stakeholders developed the SPIRIT 2013 Statement (Standard Protocol Items: Recommendations for Interventional Trials).The SPIRIT Statement provides guidance in the form of a checklist of recommended items to include in a clinical trial protocol.The main outputs are the SPIRIT 2013 Statement,14 consisting of a 33 item checklist of minimum recommended protocol items (table 1The SPIRIT 2013 Statement and E&E paper reflect the collaboration and input of 115 contributors, including trial investigators, healthcare professionals, methodologists, statisticians, trial coordinators, journal editors, as well as representatives from research ethics committees, industry and non-industry funders, and regulatory agencies.Details of the scope and methods have been published elsewhere.13 14 15 Briefly, three complementary methods were specified beforehandin line with current recommendations for development of reporting guidelines16: 1) a Delphi consensus survey15; 2) two systematic reviews to identify existing protocol guidelines and empirical evidence supporting the importance of specific checklist items; and 3) two face-to-face consensus meetings to finalise the SPIRIT 2013 checklist.

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      Friends may call at THE MCGORRAY-HANNA FUNERAL HOME OF WESTLAKE 25620 CENTER RIDGE RD. Dear Alumni: Below is the death notice of Robert R. Andolsen, Class of 1981, and Daniel Andolsen, Class of 1982. He spent his career as a counselor in private practice, retreat director at St. Past President of Embalmers Association of Cleveland. He was born in Cleveland, the son of the late Joseph and Barbara (nee Stubrich) Prell. A Memorial service with military honors will be celebrated on Thursday, May 11, 2017 at 10AM in the Chapel at Sunset Memorial Park, 6245 Columbia Rd., North Olmsted. Our parents had a love story that will live on forever in the generations to come. Singh of Rocky River, OH; her dear parents, Nicholas E. Dohms of Sheboygan, WI, and three sisters, Virginia Netter, Celeen Dohms, and Sister Mary Danielle Dohms, SSND. Further survived by many nieces and nephews as well as grand and great-grand nieces and nephews. In lieu of flowers, donations may be made to School Sisters of Notre Dame, 13105 Waterplank Road, Elm Grove, WI 53122. Dear Faculty & Staff: Below is the death notice of Matilda Bednarz, mother of Brother Dennis Bednarz, CSC. Patrick's Residence in her name would be appreciated. She was preceded in death by her father Frank Jack and a brother Robert Jack. A devoted mother and Army wife, Elaine raised her family in numerous locations in the U. After her sons were grown, she worked for 15 years as receptionist for Interstate Van Lines in Springfield, VA. John Medical Center or The Martha, Betsy, and Mary-Martha Schmitz Endowed Scholarship c/o Magnificat High School, 20770 Hilliard Rd., Rocky River, Ohio, 44116. Dear Alumni: Below is the death notice of Coletta Ansberry, mother of Jay Ansberry, Class of 1967, grandmother of Tim Ansberry, Class of 1991, Sean Ansberry, Class of 1991, Brian Ansberry, Class of 1999, and Kevin Ansberry, Class of 2002, sister-in-law of Tim Ansberry, Class of 1957, and the late Tom Ansberry, Class of 1954. ANNA COLETTA ANSBERRY (Kilcoyne), 93, went to be with her Lord and her loved ones waiting to welcome her into glory following her long and faith-filled life. Edward is humbled by the generosity expressed by our community. She lived most of her life in Cleveland's West Park. Joseph Academy, she met her beloved husband, Tony, and together raised a family and ran successful businesses in the Kamm's Corners neighborhood. He was born in Lakewood, Ohio, on July 18, 1943, the son of Robert and Alice (Healy) Gilman. Richard must have been influenced and encouraged by the Holy Cross Brothers since he joined the Brothers a month after graduating. A Funeral Mass will be held Saturday, November 5, 2016 at St. John was a retired East Cleveland Police Officer and an Honorably discharged U.

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